Microsoft Word - Draft OMB Meeting Agenda-April 11 2019

OMB Meeting 4-11-2019 Pre-read Materials

29

TN-1208

Figure 4. Tuning files _ Cyanocobalamin (m.w. 1354.5) by infusion

678.5

[M+2H + ]

1.5e7 1.4e7 1.3e7 1.2e7 1.1e7 1.0e7 9.0e6 8.0e6 7.0e6 6.0e6 5.0e6 4.0e6 3.0e6

Cyanocobalamin (CNB 12 )

604.3

689.5

602.2

709.3

2.0e6 562.9 Intensity, cps Intensity, cps 1.0e6 0.0 550 1.0e6 9.5e5 9.0e5 8.5e5 8.0e5 7.5e5 7.0e5 6.5e5 6.0e5 5.5e5 5.0e5 4.5e5 4.0e5 3.5e5 3.0e5 2.5e5 2.0e5 1.5e5 1.0e5 5.0e4 0.0

609.5

700.5 720.3 697.0

[M+H + ]

728.6 740.5 777.8

616.6657.1

845.7 858.5

903.7

1355.4

660.6

997.4 1023.5 1078.5

1144.5 1206.41281.5

638.7

1377.4

1428.2

App ID 23916

600

650

700

750

800

850

900 950 1000 1050 1100 1150 1200 1250 1300 1350 1400 1450 1500 m/z, Da

359.0

Cyanocobalamin Product of 678.5

147.0

997.5

678.4

636.0

912.6

340.6

1209.6

664.7

457.0 499.2

1124.5

930.6 1015.3

725.2

833.7

184.9

278.8

App ID 23917

100

200

300

400

500

600

700

800

900

1000

1100

1200

1300

m/z, Da

For additional technical notes, visit www.phenomenex.com

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