Microsoft Word - Draft OMB Meeting Agenda-April 11 2019

OMB Meeting 4-11-2019 Pre-read Materials

30

TN-1208

Figure 5. Tuning files _ Adenosylcobalamin (m.w. 1579.58) by infusion

[M+2H + ]

790.6

2.9e7 2.8e7 2.6e7 2.4e7 2.2e7 2.0e7 1.8e7 1.6e7 1.4e7 1.2e7 1.0e7 8.0e6 6.0e6 4.0e6

Adenosylcobalamin (AdoB 12 )

[M-Ado+2H + ]

801.5

[M+H + Na + ]

2.0e6 In tens i ty , cps Intensity, cps In tens i ty , cps In tens i ty , cps 0.0 500 1.9e6 1.8e6 1.7e6 1.6e6 1.5e6 1.4e6 1.3e6 1.2e6 1.1e6 1.0e6 9.0e5 8.0e5 7.0e5 6.0e5 5.0e5 4.0e5 3.0e5 2.0e5 1.0e5 0.0 4.2e6 4.0e6 3.8e6 3.6e6 3.4e6 3.2e6 3.0e6 2.8e6 2.6e6 2.4e6 2.2e6 2.0e6 1.8e6 1.6e6 1.4e6 1.2e6 1.0e6 8.0e5 6.0e5 4.0e5 2.0e5 100 0.0 100 8.0e5 7.5e5 7.0e5 6.5e5 6.0e5 5.5e5 5.0e5 4.5e5 4.0e5 3.5e5 3.0e5 2.5e5 2.0e5 1.5e5 1.0e5

665.5

[M+2Na + ]

812.5

527.5

676.5 687.5

880.5

948.6

673.0

550.7 566.8 580.7

755.0 823.5 838.7

989.4

App ID 23918

600

700

800

900

1000

1100

1200

1300

1400

1500

1600

1700

m/z, Da

676.5

Adenosylcobalamin Product of 790.6

801.6

603.5

728.7

971.4

362.8

234.9

200

300

400

500

600

700

800

900

1000

1100

1200

1300

1400

1500

1600

1700

m/z, Da

791.0

Adenosylcobalamin Product of 801.4

665.5

358.9

971.4

147.0

1183.3

200

300

400

500

600

700

800

900

1000

1100

1200

1300

1400

1500

1600

1700

358.9

5.0 e 4

341.0

457.0

486.2

278. 8

184.1

147.3

04/05/2019