OMB First to Final Action Recommendation Checklist 11-12-18

3/9/2017

• Regulatory Organizations • Safe level; tolerances; maximum levels (EU and Japan) REGULATORY INFORMATION

MRL ND-0.001

0.001-0.005

0.005-0.010

0.010-0.050

0.050-0.20

0.20-1.0

>1.0

MRLs.

EU

0 6

1 3

26

259

111

4

0

401 234

Japan

1

46

52

30

96

EU JEPAN Japan

300

259

250

200

150

111

96

100

52

46

30

26

50

6

4

3

1

1

0

0

0

μg/kg

ND-0.001

0.001-0.005 0.005-0.010 0.010-0.050

0.050-0.20

0.20-1.0

>1.0

5

• Regulatory Organizations • Expected concentration for identity methods (AOAC Official Method 2014.09) REGULATORY INFORMATION

250

GC-MS GC-MS/MS LC-MS/MS

GC-MS GC-MS/MS LC-MS/MS

300

250

200

200

150

150

LOQ

100

LOD

100

50

50

0

0

μg/kg

μg/kg

6

3