OMB Meeting Book (June 22, 2017)

246

MEMORANDUM 

Date:  

June 22‐23, 2017 

To: 

AOAC INTERNATIONAL Official Methods Board 

From:  

Sidney Sudberg, Chair – Committee on Statistics / OMB Member 

Subject: 

Item Vb – Summary of Activities for the AOAC Committee on Statistics

1. Progress updates 

a. Statistics for Microbiology methods validation,  

1. Testing/Validating of the new spreadsheets for both Qualitative &  Quantitative calculations actively moving forward  

b. Changes to Appendix J (after1.a.1. above complete) 

1. Quantitative methods need changes (performed during &/or after  validation)  1. Candidate minus Reference  2. New method of calculating the CI for the paired DPod  3. Use of Z (n) vs. t (n‐1)  4. Removal of reference to Welch/Satterthwaite t‐test?  5. Chi‐Square Test Calculator http://lcfltd.com/AOAC/aoac‐binary‐v2‐ 5.xlsx

c. Revising of Stat Committee’s Terms of Reference (TOR)  1. Committee should have something to review   d. Intermediate Precision (IP) Working Group:   1. Appropriate applicability for use of IP: Completed  1. SLV  2. First Action 

2. Committee on Statistics to produce a separate appendix &/or Glossary, i.e.  remove statistical details from various appendices?   1. Appendices J, K & others 

e. Appendix K Revision to begin: 

1. Terms, Definitions & its’ Measurement need to be defined  1. Intermediate Precision  2. LOD/LOQ  1. Collaborative Studies: Chondroitin Collab Study  2. Validation   3. TDRM interaction & the use of qualified Reference Standards 

f. Proficiency Testing Data for:  

g. Incremental Collab Studies