OMB Meeting Book (June 25-26, 2015)

Norma Hill and discussed in a Study Directors Education Session 11 in April 2011. The final version of the 1 guidelines was refined during September 2011 ERP meeting. 2 3 B. Resources can be identified by the AOAC Committee on Statistics. 4 5 Members of the Committee on Statistics did participate as observers during the discussions on 6 developing general SLV protocol guidance. 9 A. For quantitative methods, data demonstrating Reproducibility & Uncertainty must be present. 10 Experimental designs to collect this data may vary with the method protocol, available laboratories, 11 and the intended use of the method (i.e., collaborative studies, proficiency testing, etc…) 12 13 The ERP reviewed data statistical sheets and a Final Report 12 with multi-laboratory testing data for AOAC 14 2012.15. The data was collected using a general multi-laboratory protocol has been established by the 15 method authors, ERP chair and OMB liaison to SPIFAN ERP. Method authors drafted their own testing 16 protocols and these were forwarded to the ERP chair and the OMB liaison for their input and comments. 17 The multi-laboratory study results were submitted for the ERP’s consideration during their March 2015 18 meeting. 19 20 B. Guidance and support can be obtained from the AOAC Committee on Statistics. 21 22 The OMB liaison served as facilitator by working with both members of the AOAC Committee on 23 Statistics and the method author to ensure a sound study design for the multi-laboratory testing and to 24 ensure the appropriate statistical tools were available to analyze the data. Since this method will be 25 reviewed within ISO and IDF, members of the AOAC Committee on Statistics also reviewed the statistical 26 tool with respect to ISO standards for methods. 7 8 REPRODUCIBILITY/UNCERTAINTY:

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COMPARISON TO SMPR:

11 AOAC SPIFAN Study Directors Education Session Meeting Minutes held on April 4, 2011. 12 Zywicki, Richard and Sullivan, Darryl, Determination of Total Iodine in Infant Formula and Adult/Pediatric Nutritional Formula by Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): A Collaborative Study , 2015, Report submitted for review by ERP .

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