PFAS Meeting Book MYM 2023
Quantitation of branched PFOS (br-PFOS)
Problem response factors of isomers differ in MS/MS
accurate quantification of br-PFOS is hardly possible in routine analysis
A1
A2
A3
A4
Chromatographic separation of all isomers
yes
no
no
no
Standards of individual isomers
L-PFOS br-PFOS 1)
T-PFOS 2)
Quantification using …
Accuracy of quantification
+++
+(+)
+(+)
-
Applicable in routine analysis?
+
+++
++(+)
++(+)
1) containing L-PFOS (78.8%) + branched isomers (21.1%) analytical standard 2) containing L-PFOS (68.3%) + branched isomers (31.7%) technical grade
?
most pragmatic approach balances between accuracy and efforts/costs
• •
AOAC Midyear Meeting - Overview of EURL PFAS Guidance Document
16.03.2023
15
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