PFAS Meeting Book MYM 2023

Quantitation of branched PFOS (br-PFOS)

Problem  response factors of isomers differ in MS/MS

 accurate quantification of br-PFOS is hardly possible in routine analysis

A1

A2

A3

A4

Chromatographic separation of all isomers

yes

no

no

no

Standards of individual isomers

L-PFOS br-PFOS 1)

T-PFOS 2)

Quantification using …

Accuracy of quantification

+++

+(+)

+(+)

-

Applicable in routine analysis?

+

+++

++(+)

++(+)

1) containing L-PFOS (78.8%) + branched isomers (21.1%)  analytical standard 2) containing L-PFOS (68.3%) + branched isomers (31.7%)  technical grade

?

most pragmatic approach balances between accuracy and efforts/costs

• •

AOAC Midyear Meeting - Overview of EURL PFAS Guidance Document

16.03.2023

15