SPADA Book - April 11, 2017

Which Model Should BioWatch Adopt?

FDA ARGOS Curated database of microbial reference-grade genomes for regulatory use • Common clinical agents and near neighbors • Supporting the development of medical countermeasures • US-initiated

Livermore Metagenomic Analysis Toolkit (LMAT) Comprehensive searchable database for strain level typing • 116 billion bases of genomic data; ~5X more bacterial and viral genomic data than other databases • Microbial background characterization

FDA: Food and Drug Administration ARGOS: dAtabase for Regulatory Grade micrObial Sequences

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Quality Standards for Sequencing

Ladner et al. Mbio. 2014

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