SPADA Book - April 11, 2017

Reason 1: Soil testing aligns directly with Part 1

Proposed revisions in  Part 2 • Soil testing for robustness  against potential interferants

Current Part 1 – Interference testing  (false negatives)

– Cross‐reactivity testing  (false positives)

• Soil testing for assay specificity

Soil testing for interferants and cross‐ reactivity fits much better in Part 1 vs Part 2  on DNA testing .

Reason 2: Soil testing should apply to all SPADA SMPRs • Soil testing is relevant for non‐nucleic acid analytical  technologies (e.g., protein detection). • Current SMPRs for proteins omit Part 2 of the  Environmental Panel (e.g., SMPR 2016.011 for  Botulinum neurotoxins A1 and A2). • The introductory paragraph for the panel currently  states,  “Part 2 is not applicable to techniques that  do not detect nucleic acid.”

Moving soil testing to Part 1 would enable soil testing  to apply to all SMPRs, regardless of analytical  approach.

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