SPADA Book - April 11, 2017
Reason 1: Soil testing aligns directly with Part 1
Proposed revisions in Part 2 • Soil testing for robustness against potential interferants
Current Part 1 – Interference testing (false negatives)
– Cross‐reactivity testing (false positives)
• Soil testing for assay specificity
Soil testing for interferants and cross‐ reactivity fits much better in Part 1 vs Part 2 on DNA testing .
Reason 2: Soil testing should apply to all SPADA SMPRs • Soil testing is relevant for non‐nucleic acid analytical technologies (e.g., protein detection). • Current SMPRs for proteins omit Part 2 of the Environmental Panel (e.g., SMPR 2016.011 for Botulinum neurotoxins A1 and A2). • The introductory paragraph for the panel currently states, “Part 2 is not applicable to techniques that do not detect nucleic acid.”
Moving soil testing to Part 1 would enable soil testing to apply to all SMPRs, regardless of analytical approach.
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