SPADA at AOAC Annual Meeting 2023

ASqMi and VNGS are progressive developments

• Leonard Adleman made the first DNA computation in 1994 by using his DNA computer to solve the “’traveling salesman’ mathematical problem -- how a salesman can visit a given number of cities without passing through any city twice.” • At that time, sequencing was slow and expensive. Now it is a little different • Since that time, DNA has been used to mimic known computer logic circuits with amazing success. • If we can envision and enable synthetic DNA as a computing device, are we missing something in the potential for DNA to already be computing in living cells. • Is there a living computing system involved or is it just magical kingdom randomly operating in time and space? • Does extend to communication between and among organisms? • Is this a role for metagenomics? • Can metagenomics that includes the sequence of all of the bacteria, all of the phages and all of the hosts in a community or an ecosystem help us to understand the interactions that permit pathogens to flourish under certain conditions?