SPADA

Issues relevant to implementation of smallpox diagnostics • Biosafety: – containment; – Standard vs. Universal vs. Airborne precautions; – vaccination • Biosecurity • Reagents – WHO, CDC, select agent recommendations on use of Variola virus DNA • Centralized/regionalized testing – Transportation of specimens • QA/QC, Proficiency testing: implementation • Communication between clinician/epidemiologists/laboratory – Clinical history, case patient photos • Development of a disease confirmatory algorithm – Screening tests, confirmatory tests: regional vs. centralized – Presumed positive, Confirmed Positive – Communication of results, and public health response – Role of viral isolation by culture

LRN