SPADA

Background

 Yersinia pestis and Yersinia pseudotuberculosis are closest related  Y. pestis generally has 2 species specific plasmids (“pestoides F” exception)  Highly monomorphic but does show gene loss/gain, intra-genome recombination events, SNPs  Genetic relatedness around phenotypic groups (PE, ANT, MED, ORI)  Goal- to choose available examples from current clades

Genetic Relatedness

2010

2004

Morelli et al. 2010. Nature Genetics