SPDS Set 1 ERP Book

PDE5-005

they are linear from 50 to 1000 ppm in the sample. The consumables are inexpensive. The cost of the DART itself, compared with other DART instruments on the market, is reasonable. It would still need a highly skilled operator for the instrument. The method is very clear and easy to follow. All the parameters necessary for operation of the mass spectrometer are included in the method and easy to use. small sample size, easy extraction, ease of automation, use of MS/MS for selectivity and sensitivity, very low LOD, ability to do triggered MRM's. The data is easy and straight forward. The experimental conditions are outlined and straight forward. It uses internal standards to help with the Quantitation. The method is very specific and very selective. The optimization is very clear and straight forward. It has been optimized for the compounds of interest molecular mass. Performance Characteristics 50 - 1000 ppm in the sample, meets requirements of SMPR 2014.011 Needs the use of a highly skilled operator. Supporting Data

Method Clarity

Pros/Strengths

Cons/Weaknesses

General Comments

Method Optimization

Analytical Range:

LOQ:

50 mg/kg meets 2014.011

Average of 83.2 for all 15 compounds. Meets SMPR requirements of 2014.011

Accuracy/Recovery

Precision (RSDr)

Overall, precision meets SMPR 2014.011

Reproducibility (RSDR)

Overall, reproducibility meets SMPR 2014.011

System Suitability

Safety Review

Is the method safe to use as written? Yes Are there any safety concerns with any component, instrument, reagent or instruction of the method? If yes, please clearly state the concerns.

Yes, safety statement is there in the method.