SPDS Set 1 ERP Book

PDE5-003

Is the method safe to use as written? Yes Are there any safety concerns with any component, instrument, reagent or instruction of the method? If yes, please clearly state the concerns. Does the method include all necessary safety precautions and/or warning statements? Yes or No. If No, please suggest potential precautions or warnings that can be added to the method for users or recommend safer option(s) if warranted. yes

None that are not addressed

Recommendations

I think the weaknesses can be addressed and that this could be a very valuable screening method for PDE5 inhibitors and related inhibitors.

Final Recommendation: