SPDS ERP CVs - DEC 2017

Mark S. Lowenthal, Ph.D. National Institute of Standards and Technology 100 Bureau Dr. Gaithersburg, MD 20899 Mark.Lowenthal@nist.gov 301-975-8993

Work Experience National Institute of Standards & Technology (NIST)

Sept 2007 – present

Gaithersburg, MD

• Development of a glycan-based Standard Reference Materials • Development of Proteomics-Based Methods for Protein Quantification • Improving Measurement Quality in Clinical Proteomics • Development of Reference Methods and Reference Materials for the Determination of Cardiac Troponin I in Human Serum • Development of a Reference Measurement Procedure for C-Reactive Protein in Human Serum • Development of an Amino Acid (in Solution) Standard Reference Material • Development of Reference Methods and Reference Materials for Proteins • Development of tools for improvement of microbial food safety • Quantification of vitamins, metabolites, proteins, carbohydrates, and amino acids in biofluids, food products, dietary supplements • Provide maintenance of GC/MS and LC/MS instrumentation • Mentoring of post-docs, graduate students, and undergraduates • Project leader for Standard Reference Materials development • Skills: mass spectrometry, measurement sciences, immunoassay development, chromatography, western blot, electrophoresis, separations, cell culture, molecular biology, protein expression, magnetic particle synthesis Cellona Therapeutics, Inc. Sept 2013 – present Highland, MD • Consulting and advising – assay development/planning for start-up company targeting cancer therapeutics and drug design for inhibiting signaling proteins involved in cancer growth • Development of small molecule quantification assays from rat plasma, validation of pharmacokinetic studies University of Colorado, Health Sciences Center Aug 2005 – Aug 2007 Aurora, CO • Postdoctoral research fellowship – Depart. of Cellular and Developmental Biology • Proteomics of lipid droplet biogenesis in mammalian cells, secretion from mammary epithelial tissue • Organellar fractionation, LC-MS/MS quantification of complex protein/peptide mixtures isolated from tissue and cell lysates • Characterization of protein post-translation modifications, functional studies of protein domains of adipophilin • Skills: mass spectrometry, chromatography (LC, GC), immunofluorescence light microscopy, electron microscopy, western blotting, immunoprecipitation, mammalian cell culture, organellar fractionation, phosphopeptide analysis, 2D gel electrophoresis, 2D LC