SPDS eBook March 2017

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Challenge: SAMe’s Extreme Instability

Techniques to Reduce SAMe Product Degradation

1) Chemical Method

Binding SAMe molecule with some compounds e.g. Trehalose, Toluenesulfonic Acid Binding sites: -COOH, -NH2, S

Challenge: SAMe’s Extreme Instability

Techniques to Reduce SAMe Product Degradation

2) Physical Method

„ Tablets - Enteric Coating „ Temperature - Refrigeration, Freezing „ Oxygen Trap Î Shelf Life - Two years for current SAMe tablets Î However, does not stop Racemization

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