SPDS eBook March 2017

General Analytical Needs

▪ The industry needs an accurate quantitative and qualitative analytical method to determine the amount of SAMe in the product for quality control; ▪ Also use the method to do product stability studies to develop a better product.

Existing Analytical Methods (General) ▪ Cation Exchange HPLC Column expensive, not accurate, hard to do; ▪ NMR Method Not for regular QC labs to use; instrument expensive, not accurate;

▪ UV Method Simple, but not accurate;

▪ Regular HPLC Method The best approach with the current analytical techniques