SPIFAN Nutrients ERP Info to OMB

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EXPERT REVIEW PANEL Stakeholder Program on Infant Formula and Adult Nutritionals (SPIFAN) DOCUMENTS REVIEW

November 18, 2022

AOAC INTERNATIONAL 2275 Research Blvd. Ste. 300 Rockville, MD, 20850 UNITED STATES

dboyd@aoac.org 301.924.7077 x12



November 9, 2022


AOAC Official Methods Board (OMB)

FROM: Delia Boyd, Senior Manager SUBJECT: AOAC SPIFAN Nutrients Expert Review Panel (ERP)

Background: In accordance with the policy for Official First Action, an expert review panel is being assembled to review methods submitted into the AOAC SPIFAN process for priority nutrients. AOAC staff has collected CVs and they are on file at AOAC in accordance with the revised ERP policiesand procedures. A proposal for the AOAC SPIFAN Expert Review Panel is submitted for your consideration.

The attached package contains the following information: CVs for all proposed candidate(s)

 List of Expert Review Panel (ERP) members  Balance of Perspectives  CVs

This expert review panel operates under AOAC policies and procedures. Each expert is required to sign the AOAC Volunteer Acceptance Form which includes adherence to the AOAC policy for Volunteer Conflict of Interest, Antitrust and Use of Association Name, Letterhead and Logo. These documents will be enforced by the Expert Review Panel chair and facilitated by AOAC staff. We request the OMB to review and confirm the expertise of proposed candidates also reviewing the balance of the panel as well as the conflicts of interest of proposed members. This Expert Review Panel is scheduled to meet “Virtually” on December 7, 2022. Your review and approval of the panel is requested. Please address questions regarding the attached package to me and thank you for your consideration. Recommendation: To remove name(s) for vetting SPIFAN Nutrients Expert Review Panel (ERP)

1. Esther Campos-Gimenez

Société des Produits Nestlé


To add name(s) for vetting SPIFAN Nutrients Expert Review Panel (ERP)

2. Christophe Fuerer

Société des Produits Nestlé


AOAC INTERNATIONAL Stakeholder Panel on Infant Formula & Adult Nutritionals (SPIFAN) Nutrients Expert Review Panels (ERP) November 9, 2022 NUTRIENT PANEL 1. Darryl Sullivan (ERP Chair) Eurofins US 2. Sean Austin (FOS/GOS Only) Christophe Fuerer Société des Produits Nestlé 3. Sneh Bhandari Independent Consultant 4. Hans Cruijsen/Martine van Gool FrieslandCampina 5. Brendon Gill Fonterra Cooperative 6. Karen Schimpf/Philip Haselberger (HMO Only) Abbott Nutrition 7. Estela Kneeteman INTI 8. Maria Ofitserova Pickering Labs 9. Thomas Vennard/Shay Phillips Reckitt 10. Melissa Phillips/Kate Rimmer NIST 11. Yannis Vrasidas (HMO Only) Consultant 12. David Woollard Independent Consultant 13. Jinchuan Yang Waters Corporation

Christophe Fuerer , PhD Société des Produits Nestlé SA

Nestlé Research Route du Jorat 57 1000 Lausanne 26 Switzerland +41 21 785 80 16 christophe.fuerer@rdls.nestle.com Experience Société des Produits Nestlé SA , Nestlé Research , Switzerland

06/2014 – present Senior Specialist (2018-present) Proteins Analysis , mass spectrometry, analytical chemistry & Proteins Specialist (2014-2018) Proteins Analysis , mass spectrometry, analytical chemistry & Proteins  Manage the Nestlé portfolio of analytical protein methods, evaluate proficiency tests, develop and validate analytical methods, liaise with standardization bodies, provide expert assistance to quality assurance centers, R&D centers, and factories, supervise lab technicians, and coordinate lab work  Mass Spectrometry  Intact protein analyses (proteoform fingerprinting and quantification) by UHPLC-HRMS, with an emphasis on the detection of genetic variants and protein glycation  Multiple Reaction Monitoring (MRM) methods for absolute quantification of trace allergens in food matrices and milk proteins in dairy matrices  Method development and validation  Intact protein fingerprinting, detection, and quantification of milk proteins by UHPLC-HRMS  Amino acids in food matrices by UHPLC-UV  Whey protein content by capillary gel electrophoresis  Trace amounts of intact proteins by gel electrophoresis  Method standardization and active contribution to standardization bodies  AOAC International  Total Amino Acids by UHPLC-UV (Final Action 2018.06, author)  Whey protein content in infant formula by SDS-CGE (Final Action 2016.15, author)  A1- and A2-type beta casein (accepted SMPR, working group member)  Lactoferrin (SMPR 2020.005, working group member)  Food allergens by MS (SMPR 2016.002, working group member)  IDF/ISO  Total Amino Acids by UHPLC-UV (DIS in discussion, author)  Whey protein content by SDS-CGE (IDF 247, ISO 23293, author)  Evaluation of nitrogen conversion factors (IDF Bulletin, co-author)  USP  Detection of foreign proteins in whey (FCC, Appendix XVI, author)  Revision of whey monographs with focus on authenticity (expert panel member)  CEN  Protein and amino acid analyses in algae (TC454/WG7 - Algae and algae products, Product test methods - saccharides, proteins, amino-acids, panel member)

EPFL (Ecole Polytechnique Fédérale de Lausanne) , Switzerland

01/2009 – 05/2014

Research Associate , biochemistry, cellular biology & mass spectrometry  Developed a quantitative LC-MS/MS analytical assay for early markers of Alzheimer’s disease  Developed growth factors purification workflows and companion analytical assays

Stanford University , California, USA

04/2005 – 11/2008

Research Associate , cellular biology, stem cells, biochemistry  Purified and stabilized bioactive growth factors prone to aggregation  Generated lentiviral vectors (1000+ vectors distributed worldwide)

ISREC (Institut Suisse de Recherche Expérimentale sur le Cancer) , Switzerland

11/1999 – 12/2004

PhD student and Postdoctoral fellow , oncology, viral therapy  Created complex replicating oncolytic adenoviruses


Mass spectrometry:

Intact protein analyses by UHPLC-HRMS, absolute protein quantification by Parallel and Multiple Reaction Monitoring (PRM/MRM), peptide profiling by LC-MS/MS

Separation techniques: HPLC/UHPLC, capillary gel electrophoresis, gel electrophoresis Biology/biochemistry: bioactive protein purification, reporter assay development, stable cell line generation Virology: lentiviruses, replicating adenoviruses Education

Ph.D. (Life Sciences), Université de Lausanne , Faculté de Biologie et de Médecine

2004 1999

M.Sc. ( Biochemistry), Université de Genève , Faculté des Sciences

Continuous education

Project management fundamentals

Nestlé, Lausanne, 2018

Intent-based leadership

Turn the Ship Around, LLC. Lausanne, 2016

Method validation

Nestlé, Lausanne, 2015

Business plan and Startup development

Venture Challenge, CTI, Lausanne, 2013-2014

Safety coordinator

SUVA, Lausanne, 2012


CEN (European Committee for Standardization, panel member) USP (United States Pharmacopeia, expert panel member)

since 2022 since 2018 since 2018 since 2016 since 2015 since 2014 since 2000

SNV (Schweizerische Normen-Vereinigung, subcommittee on Milk and milk products, member)

AOAC International (method author, SMPR working groups) IDF (International Dairy Federation, SCAMC, Action team, Task force)

SGMS (Swiss Group for Mass Spectrometry) LS2 (Life Sciences Switzerland, formerly USGEB)


English C2 German B1+

Intensive B1+ course, Wessex Academy, Lausanne, 2013


Mother tongue

Selected publications

(complete list at http://tinyurl.com/cfuererpub)

2020 Protein Fingerprinting and Quantification of β-Casein Variants by Ultra-Performance Liquid Chromatography High-Resolution Mass Spectrometry , Fuerer C, Jenni R, Cardinaux L, Andetsion F, Wagnière S, Moulin J, Affolter M, J Dairy Sci, 103(2):1193-1207 2019 Total Amino Acids by UHPLC-UV in Infant Formulas and Adult Nutritionals, First Action 2018.06 , Jaudzems G, Guthrie J, Lahrichi S, Fuerer C, J AOAC Int, 102(5):1574-1588 2018 Quantification of Whey Protein Content in Milk-Based Infant Formula Powders by Sodium Dodecyl Sulfate – Capillary Gel Electrophoresis (SDS-CGE): Multi-Laboratory Testing Study, Final Action 2016.15 , Feng P, Fuerer C, McMahon A, J AOAC Int, 101(5):1566-1577 2017 Quantification of Whey Protein Content in Infant Formulas by Sodium Dodecyl Sulfate-Capillary Gel Electrophoresis (SDS-CGE): Single-Laboratory Validation, First Action 2016. 15, Feng P, Fuerer C, McMahon A, J AOAC Int, 100(2):510-521


ERP Members by Region

ERP Members by Perspective

AOAC SPIFAN Nutrients ERP Members by Perspective

Academia 0%

CRO 12%

Government 18%

Academia CRO Government Industry

Industry 70%

AOAC OFFICIAL METHODS BOARD (OMB) Review of AOAC SPIFAN Members e-Ballot November 9, 2022

Click here to complete the form or copy link below into browser https://form.jotform.com/223148818917162

Deadline date is December 5, 2022

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