AOAC SPSFAM Meeting Book 9-24

Draft AOAC SMPR 2017.XXX; Version 7; July 11, 2017 1 2 D etermination of free Bisphenol A (BPA) in commercially packaged ready to consume 3 carbonated and non-carbonated water and non-alcoholic beverages 4 5 Purpose: AOAC SMPR’s describe the minimum recommended performance characteristics to be 6 used during the evaluation of a method. The evaluation may be an on-site verification, a single- 7 laboratory validation, or a multi-site collaborative study. SMPRs are written and adopted by 8 AOAC Stakeholder Panels composed of representatives from the industry, regulatory 9 organizations, contract laboratories, test kit manufacturers, and academic institutions. AOAC 10 SMPRs are used by AOAC Expert Review Panels in their evaluation of validation study data for 11 method being considered for Performance Tested Methods or AOAC Official Methods of 12 Analysis , and can be used as acceptance criteria for verification at user laboratories. 13 14 Approved by: Stakeholder Panel Strategic Food Analytical Methods (SPSFAM) 15 16 Intended Use: Surveillance and monitoring by trained technicians.

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1. Applicability:

D etermination of free Bisphenol A (BPA) in commercially packaged ready to consume carbonated and non-carbonated water and non-alcoholic beverages listed in table 3.

2. Analytical Technique:

Any analytical technique that meets the following method performance requirements is

acceptable.

3. Definitions:

Accuracy 1

The closeness of agreement between the average of an infinite number of replicate

measured quantity values and a reference quantity value.

Bisphenol A (BPA)

IUPAC name: 4,4'-(propane-2,2-diyl) diphenol. CAS registry number: 80-05-7. See figure 1

for chemical structure.

Limit of Detection (LOD)

The smallest amount or concentration of an analyte that can be estimated with acceptable reliability. Estimated as the: LOD = blank mean + 3 standard deviations of ten independent analyses of blank or blank spiked at low level (to be agreed upon by Study Directors) (if there is no detectable blank signal). See reference to Appendix L in

section 7. Validation Guidance.

Limit of Quantitation (LOQ)

The minimum concentration or mass of analyte in a given matrix that can be reported as a quantitative result. Determined as: LOQ = blank mean + 10 standard deviations (concentration of blank to be <10% of the estimated LOQ.) Appendix L.

1 Corresponds to the VIM definition for “truness”.

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