AOAC SPSFAM Meeting Book 9-24

9/21/2017

Content

 AOAC China Meeting and Vet Drugs Session  What is Happening in China on Vet Drugs  Feedback of Chinese Stakeholders on the Vet Drugs Methods

Feedback of Chinese Stakeholders on the Vet Drugs Methods

I. Numbers of compounds to regulate

1. >200 analytes for China market, yet need to consider the reality of how many analytes could be covered in a single method 2. Easy-to-get compounds should be of high priority 1. Screening method needs to be highly efficient. The more analytes and matrices to cover, the more applicable the method is. Same pretreatment can be applied to similar matrices. First to validate matrices of the most consumption, eg. milk, egg, poultry, pork, fish, (honey?) etc. 2. Or, some analytes might be used only in specific scenario (eg. metronidazole is only found in egg), and have different levels of residue in different matrices, should consider “analyte + matrix” as a combination to develop method 3. Or, first to separately evaluate analytes and matrices, and then to combine the comparable matrices and pretreatment methods to promote efficiency 4. Besides fresh food materials, processed food product should also be involved in validation 1. GB will focus on confirmatory methods (LC-MS/MS) in short term due to cost, universality and skill level 2. China is making great efforts to be in line with International standards, hereby the HRMS has potential to develop quickly in Chinese markets and laboratories 3. In long term view, HRMS represents the trend of development. Currently most CIQ and CDC laboratories are equipped with HRMS, thus makes it possible to have a SN standard on HRMS screening soon 4. For compliance purpose, LC-MS/MS is necessary; for risk assessment and manufacture use, HRMS is more efficient 1. GB is used for domestic and imported food; SN is used for exported food. 2. Many GB on vet drug residues are based on SN standards 3. Many CIQs had established HRMS method (with QuEChERS, multiple matrices) for vet drug residues 1. There are different requirements for GB, SN or FDA standards in China. 2. The GB requirement is relatively rough, while many SN requirements are adopted from AOAC SMPR. 3. The revision and consolidation of these requirements are being planned. 1. The vet drug residue in feedstuffs usually is at relatively high concentration and has lower risk. 2. The amount of relevant standards is small. There are standards being formulated. 3. HRMS is also suitable to screen vet drug residue in feedstuffs 1. Representatives from CIQ, CDC and FDA expressed willingness to participate in and collaborate with the AOAC International working panel on vet drug residues 5. LC-MS/MS and HRMS could share the same pretreatment procedure 6. CAIQ has submitted GB draft method for pesticides using HRMS

II. How many methods for different analytes/matrices

III. Confirmatory method or screening method

IV. GB and SN in CIQ

V. Method performance requirement

VI. Vet drug residue in feedstuffs

VII. Contribute to AOAC from China

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