September 2016 SPSFAM Book

9/13/2016

Stakeholder Panel on Strategic Food Analytical Methods: Background and Fitness for Purpose for Proanthocyanidins in Cranberry Products Brian Schaneberg Dallas, TX September 18, 2016

Background on the Analyte

▪ Cranberry juice has been used traditionally for the treatment and prevention of urinary tract infections ▪ Effectiveness first demonstrated by Avorn, et. al. in a randomized, double-blind, placebo-controlled study in 1994 ▪ Sobota first proposed a bacterial ( E. Coli ) anti-adhesion (uroepithelial cell) mechanism for cranberry in 1984 ▪ Howell, et. al. used an anti-adhesion bioassay directed fractionation of cranberry juice and identified A-Type proanthocyanidins as the active components in 1998 ▪ Feliciano, et. al. have also shown A-type PACs inhibited gut colonization of uropathogenic E. coli in 2013

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