SPSFAM EXPERT REVIEW PANEL

1. Are the definitions specified in the SMPR used and applied appropriately in the supporting documentation (manuscripts, method studies, etc...)? If not, please explain the differences and if the method is impacted by the difference. 2. Is there information demonstrating that the method meets the SMPR Method Performance Requirements using the Reference Materials stated in the SMPR? If not, then specify what is missing and how this impacts demonstration of performance of the method. method performs within the SMPR Method Performance REquirements table specifications for all analytes in the SMPR applicability statement? If not, please specify what is missing and whether or not the method's applicability should be modified. 1. Based on the supporting information, were there any additional steps in the evaluation of the method that indicated the need for any additional precautionary statements in the method? 2. Does the method contain system suitability tests or controls as specified by the SMPR? If not, please indicate if there is a need for such tests or controls and which ones. 3. Is there information demonstrating that the method system suitability tests and controls as specified in the SMPR worked appropriately and as expected? If no, please specify. 3. Is there information demonstrating that the

Detection limit may have not been estimated according to the definitions specified in the SMPR. Repeatability was demonstrated using standard solutions (<= 2.5 nmol/L) only instead of real samples spiked with standards.

Other than the standard solutions, there are no additional reference materials used in the method.

The method was demonstrated to perform within the SMPR specifications in terms of detection limit and repeatability only for drinking water, but not for the other beverage products specified in the SMPR.

The detection limit should be estimated according to the definitions specified in the SMPR. Repeatability should also be evaluated using real samples for the analytical ranges specified in the SMPR.

No. Background contamination is very common for BPA analysis, and method blanks should always be included during analysis.

Not available.