SPSFAM EXPERT REVIEW PANEL

2. Does the method contain system suitability tests or controls as specified by the SMPR? If not, please indicate if there is a need for such tests or controls and which ones. 3. Is there information demonstrating that the method system suitability tests and controls as specified in the SMPR worked appropriately and as expected? If no, please specify. 4. Based on the supporting information, is the method written clearly and concisely? If no, please specify the needed revisions. 5. Based on the supporting information, what are the pros/strengths of the method?

The missing point for this method is system suitability test parameters results. The authors should be demonstrate the suitability of the developed HPLC-FL method.

They may be support their results with data

The methods written well, step by step, clearly and concisely. The developers of the method can be used molarity instead of normality while they indicated the concentration of the solutions.

The strengths of the method following: * The HPLC system with FL detection can be found in many analytical laboratories, * Immunoaffinity purification concentrate the samples for better accuracy * Apart from the immunoaffinity columns, the reagents and chemicals can be found easily *The specificity of the method is good enough The weakness of the methods: *Immunoaffinity purification suffers time when the rapidness is essential * The degradation products or possible impurities should be mentioned and the developers could demonstrated the specificity of their method. *Recovery of the method decreased whenever the spiked amount of BPA was increased (May be the immunoaffinity column need to be rechecked and reoptimized) *Some statements like "the type of sample preparation may be used in other type of drinks" not clear. These parts may need to be clarified.

6. Based on the supporting information, what are the cons/weaknesses of the method?

7. Any general comments about the method?

In general the other type of samples like tea, coffee, energy drinks, etc. may be applied and included.

V. Final Recommendation Do you recommend this method be adopted as a First Action and published in the Official Methods of Analysis of AOAC INTERNATIONAL? Please specify rationale.

The method seems easy to operate instead of sample preparation part. However sample preconcentration may be important in some cases and somehow it will be worth to be used. After some revisions this method can be adopted and published.