SPSFAM EXPERT REVIEW PANEL

3. Is there information demonstrating that the method system suitability tests and controls as specified in the SMPR worked appropriately and as expected? If no, please specify. 4. Based on the supporting information, is the method written clearly and concisely? If no, please specify the needed revisions. 5. Based on the supporting information, what are the pros/strengths of the method? 6. Based on the supporting information, what are the cons/weaknesses of the method?

Blank samples appear to be blank. I would like to see calibration information as well as recovery of a BPA solution from the SPE cartridge. Some of the chromatograms are very busy - I would like to see criteria around the identification of the BPA peak as well.

Much more information is needed. The method is very bare bones. Information about solution preparation and calibration is the most glaring omission.

Straightforward, and appears to work for spikes in cola and infant formula.

No LOD, LOQ, or analytical range data. No samples tested in the high range (5-20 ug/L). This concerns me from a standpoint of SPE cartridge overload - specific instructions are needed related to cartridge capacity for BPA and whether samples should be diluted. How would one know if an unknown sample (with an unknown amount of BPA) has overloaded the cartridge?

I would also like to see data in more of the matrices.

7. Any general comments about the method?

This method has potential, but more work is needed before the SMPR is met.

Do you recommend this method be adopted as a First Action and published in the Official Methods of Analysis of AOAC INTERNATIONAL? Please specify rationale.

Not at this time.

I would recommend that the authors provide the following information and resubmit:

1. Information about calibration and analytical range 2. Information about LOD and LOQ 3. Testing of samples at higher concentrations (5-20 ug/L) 4. Testing of additional matrices in Table 3 5. submit procedures used for background assessment and control, and frequency of analysis of method blanks