SPSFAM EXPERT REVIEW PANEL

1. Are the definitions specified in the SMPR used and applied appropriately in the supporting documentation (manuscripts, method studies, etc...)? If not, please explain the differences and if the method is impacted by the difference. 2. Is there information demonstrating that the method meets the SMPR Method Performance Requirements using the Reference Materials stated in the SMPR? If not, then specify what is missing and how this impacts demonstration of performance of the method. method performs within the SMPR Method Performance REquirements table specifications for all analytes in the SMPR applicability statement? If not, please specify what is missing and whether or not the method's applicability should be modified. 1. Based on the supporting information, were there any additional steps in the evaluation of the method that indicated the need for any additional precautionary statements in the method? 2. Does the method contain system suitability tests or controls as specified by the SMPR? If not, please indicate if there is a need for such tests or controls and which ones. 3. Is there information demonstrating that the method system suitability tests and controls as specified in the SMPR worked appropriately and as expected? If no, please specify. 3. Is there information demonstrating that the

The manuscript states that RSDr was estimated based on analysis of multiple samples (n=3) on 2 different days (total n=6). This

Yes. Spike recovery data are provided, for canned energy drinks in the attached publication. Within day (n=3) and day to day (n=6) data are used to demonstrate accuracy and precision in the absence of a reference material.

Yes. Method meets the requirements for one of the matrices listed in the SMPR. Data for other matrices would be needed to demonstrate broad applicability to other beverages listed.

Specificity of the method is reliant on the clean up using SPE with molecularly imprinted polymers. Data presented demonstrate binding of other bisphenol A related compounds (e.g., BPB, BPF, BADGE, and BFDGE). Specificity in other matrices should be demonstrated to minimize potential for false positive results.

Supporting document describes procedure blanks and glass washing procedures to monitor background contamination. Final method should include these steps as requirements.

Yes. Background contamination was not reported based on the controls used.