SPSFAM EXPERT REVIEW PANEL

4. Based on the supporting information, is the method written clearly and concisely? If no, please specify the needed revisions. 5. Based on the supporting information, what are the pros/strengths of the method?

The procedure documented in the manuscript must be written in method form. The submitted document provides an overview of the procedure used, but does not include sufficient detail to be executed in another laboratory.

Sample preparation using the SPE molecularly imprinted polymer cartridge is simple and easily reproduced. Implementation on the UPLC platform with fluorescence detection is simple and readily accessible by most labs. Supporting documents indicate applicability using either GC-MS or LC-MS/MS for labs with those capabilities, but performance data are limited using these instrument platforms.

6. Based on the supporting information, what are the cons/weaknesses of the method?

The method is specific to a proprietary technology from a single vendor and is highly dependent on the consistency and quality control of the manufacturing process.

7. Any general comments about the method?

Implementation on GC-MS or LC-MS/MS instrument platforms would improve the specificity and probable applicability of the method to a wide variety of beverages with less concern about potential matrix interference. Not at this time. The method as documented in the provided manuscript demonstrates good potential to meet the SMPR, but additional work is recommended. The method would need to be written in AOAC method format. In addition, due to the demonstrated non-specific binding of BPA related compounds, method validation using a wider array of matrices is recommended.

Do you recommend this method be adopted as a First Action and published in the Official Methods of Analysis of AOAC INTERNATIONAL? Please specify rationale.