Statistics Meeting Book (2-22-17)

AOAC INTERNATIONAL COMMITTEE ON STATISTICS Draft Meeting Agenda Wednesday, February 22, 2017 Meeting Start Time: 11:00AM (Eastern US)

Chair: Sidney Sudberg (Alkemists Pharmaceuticals) ______________________________________________________________________________

( Need member to volunteer to take the minutes )

I. WELCOME & INTRODUCTION (Sudberg – 11:00AM‐11:10AM) *

Sidney Sudberg will call the meeting to order, welcome and introduce the members of Statistics Committee. Members will review the AOAC policy documents and vote on the draft meeting agenda.

II.

REVIEW OF MEETING MINUTES (All – 11:10AM-11:15AM)* The members of the Statistics Committee will review and vote on the January 18, 2017 meeting minutes.

III.

CURRENT METHOD CONFORMITY ASSESSMENT PROJECTS (Wehling/LaBudde/Sudberg/Thompson/Graves – 11:15AM-11:35AM) (Progress updates) a. Statistics for Microbiology methods validation (discuss internal validation plan) -Paul Wehling & Robert LaBudde (Leads) Volunteers: 1. Caryn Thompson 2. Qian Graves 3. Jane Weitzel 4. Mike Zapf 5. Hilde Skår Norli 6. Sidney Sudberg

b. Changes to Appendix J -Paul Wehling & Robert LaBudde (Leads) 1.

Quantitative methods need changes (performed during validation?) i. Candidate minus Reference ii. New method of calculating the CI for the paired DPod iii. Use of Z (n) vs. t (n-1) iv. Removal of reference to Welch/Satterthwaite t-test?

c.

Chi-Square Test Calculator -All http://lcfltd.com/AOAC/aoac-binary-v2-5.xlsx 1. To be handled with Appendix J changes

d. Revising the Statistics Committee’s Terms of Reference (ToR) 1. Latest version to be distributed by Staff i.

To be distributed to members of the Committee this month,

e. Statistics Advisor Review Form -Caryn Thompson & Robert LaBudde (Leads) 1. The committee has decided to modify the form on the AOAC web into a combined form for Quantitative, and Qualitative. Robert and Caryn are taking lead on the new forms (Qualitative and Quantitative). 2. Staff to distribute to Committee for review.

*Requires a vote

version 1

Draft meeting agenda is subject to change without notice