Statistics Meeting Book (2-22-17)

RSD i

 Definition

 Acceptance Criteria

OMB Discussion on Method Format & Performance Characteristics (2-8-17)

 Guidance

 Relationship ---> RSD i

---> RSD R

 Relationship ---> RSD i

---> RSD r

LOD w/RSD r

LOQ definition

PoD (currently in 4 different AOAC appendices)

LLA/MDL

Statistics

Accuracy vs Recovery vs Mean Recovery

Measurement Uncertainty (MU)

PoD

 False +/- Rate

 False +/- Risk

PoD

How is RSD R

assessed (other than Horrat)

Proficiency Testing

Include RSD i

in SMPR

Include RSD i

in method

Inclusion of data in method

SMPR

Interference/Inhibition

Harmonization

Guidance

(ISO/AFNOR/CODEX)

Org.

Accuracy

 Reference method comparison  Validation & data assessment

What to do when no reference method is available

Micro

Schedule

 Next edition of OMA – Spring 2018

Retrofit SMPRs

Pubs