Statistics Meeting Book (February 14, 2018)

AOAC INTERNATIONAL COMMITTEE ON STATISTICS Draft Meeting Agenda Wednesday, February 14, 2018 Meeting Start Time: 11:00AM (Eastern US) Chair: Sidney Sudberg (Alkemist Labs) ______________________________________________________________________________ ( Need member to volunteer to take the minutes )

I. WELCOME & INTRODUCTION (Sudberg – 11:00AM‐11:10AM) *

Sidney Sudberg will call the meeting to order, welcome and introduce the members of Statistics Committee. Members will review the AOAC policy documents and vote on the draft meeting agenda.

II. REVIEW OF MEETING AGENDA & MINUTES (All – 11:10AM-11:15AM) * The members of the Statistics Committee will review and vote on the January 10, 2018 meeting minutes and the February 14, 2018 meeting agenda.

III.

CURRENT METHOD CONFORMITY ASSESSMENT PROJECTS (Wehling/LaBudde/Sudberg/Thompson/Graves – 11:15AM-11:35AM)

Progress updates a. Statistics for Microbiology Methods Validation - Paul Wehling & Robert LaBudde (Leads) 1. Progress for Internal Validation Plan a. Waiting for Update from Robert &/or Paul?

Volunteers: 1. Caryn Thompson

4. Mike Zapf 5. Hilde Skår Norli 6. Sidney Sudberg

2. Qian Graves 3. Jane Weitzel

b. Changes to Appendix J (in progress) - Paul Wehling & Robert LaBudde (Leads) 1. Quantitative methods need changes (performed during &/or after validation) a. Candidate minus Reference b. New method of calculating the CI for the paired dPod c. Use of Z (n) vs. t (n-1) d. Removal of reference to Welch/Satterthwaite t-test? e. Chi-Square Test Calculator (Robert/Paul) http://lcfltd.com/AOAC/aoac-binary-v2-5.xlsx i. To be discussed with Appendix J changes c. Statistics Committee’s Terms of Reference (ToR) Update – All, ToR Subcommittee 1. Latest version – v8 has been approved by OMB a. Waiting for Staff guidance on what is next

*Requires a vote

version 1

Draft meeting agenda is subject to change without notice