Statistics Meeting Book (June 20, 2017)

Version 1.1

AOAC QUALITATIVE STUDY STATISTICAL REVIEW CHECKLIST DOCUMENT ID: ______________________________________________________ Approve __ Changes needed, no review __ Changes needed, new review __ Reject __ (Place ‘N’ beside any of the below where a defect is found.) TITLE: 1. __ Is the analyte stated? 2. __ Is the AOAC method identifier stated? 3. __ Is the type of study described (PTM vs. SLV vs. MLV, etc.)? ABSTRACT: 4. __ Are required measures of effect reported, along with 95% confidence intervals? 5. __ Are results reported separately for each matrix? 6. __ Are results reported for repeatability and reproducibility with 95% confidence intervals? 7. __ Is the use of unjustified compositing across matrices or collaborators avoided? 8. __ Are any hypothesis test results reported in proper form and is the observed confidence interval on measure of effect used to assess any conclusion drawn? 9. __ Is the study identified as matched (paired) or unmatched (unpaired) in methods to replicates? 10. __ Are the reported results free of improper generalization? INTRODUCTION: 11. __ Is the current state of the art for the same analyte and matrices properly reviewed? 12. __ Is the previous history of the candidate method reviewed? METHOD & MATERIALS: 13. __ Are the matrices unambiguously defined sufficiently to allow reproduction of the study? 14. __ Are the sampling and method of preparation described adequately? 15. __ Is the mixing of the samples homogeneous, and is there validation given for this? 16. __ Is the method of removal of test portions precisely defined so as to indicate preclusion of possible correlation of results? 17. __ Are outliers excluded solely for physical cause, which has been identified and supported by objective proof? 18. __ Are the required minimum number of replicates performed? 19. __ Are the required minimum number of collaborators used? 20. __ Is the study identified as matched (paired) or unmatched (unpaired) in methods to replicates? 21. __ Are the test portion replicates adequately randomized and masked with respect to preparation and distribution to collaborators?