Statistics Meeting Book (December 19, 2018)

a. Statistics for Microbiology Methods Validation - Paul Wehling & Robert LaBudde (Leads) 1. Word copies of the Annexes for Appendix J, provided, to be able to work with equations easily: a. Robert LaBudde b. Paul Wehling

Volunteers to check equations modified by Paul: 1. Qian Graves 2. Jane Weitzel

3. Hilde Skår Norli 4. Sidney Sudberg

Qian has assisted Paul, and has copy-pasted all the missing formulae from the original document that Robert shared with us into Paul’s new revising document. Paul will revise some of the formulae that needed to be changed using MATHTYPE software. Paul can get this done after 2 weeks when he has some time, and it will be before the next monthly call, and he will share the file with the others.

b. Changes to Appendix J (in progress) - Paul Wehling & Robert LaBudde (Leads) 1. Quantitative methods need changes (performed during &/or after validation) a. Candidate minus Reference b. New method of calculating the CI for the paired dPod c. Use of Z (n) vs. t (n-1) d. Removal of reference to Welch/Satterthwaite t-test? e. Chi-Square Test Calculator (Robert/Paul) http://lcfltd.com/AOAC/aoac‐binary‐v2‐5.xlsx i. To be discussed with Appendix J changes c. Statistics Committee’s Terms of Reference (ToR) Update – All, ToR Subcommittee 1. Latest version – v8 has been approved by OMB a. Sent to Committee on Statistics b. Board of Directors to vote via e-Ballot?

Sidney asked Delia what is the latest news about the BoD’s voting for the new ToR? Delia has heard that they will do an e-Ballot, and she will keep the committee posted once it is approved.

*Requires a vote

version 3

Draft meeting agenda is subject to change without notice