the Stakeholder Panel on Dietary Supplements

86 87 88 89 90 91 92 93 94 95 96 97 98

8. Validation Guidance :

Method must be able to separate SAMe from decomposition products (Table 3) and synthetic precursors (Table 4), and quantify total SAM-e in the presence of stabilizing agents

(Table 5).

Appendix D: Guidelines for Collaborative Study Procedures to Validate Characteristics of a Method of Analysis; 19 th Edition of the AOAC INTERNATIONAL Official Methods of Analysis

(2012). Available at: http://www.eoma.aoac.org/app_d.pdf

Appendix K: Guidelines for Dietary Supplements and Botanicals 19 th Edition of the AOAC INTERNATIONAL Official Methods of Analysis (2012). Also at: . AOAC Int. 95, 268(2012); DOI: 10.5740/jaoacint.11-447 and available at: http://www.eoma.aoac.org/app_k.pdf

99 100 101 102 103 104 105

9. Maximum Time-To-Determination:

No more than 30 minutes.