the Stakeholder Panel on Dietary Supplements

Proposed Fitness for Purpose ▪ The method identifies and quantifies the six primary kavalactones derived from the underground portions of kava ( Piper methysticum ), namely desmethoxyangonin, dihydrokavain, yangonin, kavain, dihydromethysticin, and methysticin in plant material, dietary ingredients and dietary supplements. The ability of the method to also identify and quantify flavokavains A, B, and C is optional. Test results can be used in chemotype identification but this specific determination is outside the method scope. Individual kavalactones should be quantifiable within the range of 0.1 to 50 percent by weight in forms that include liquid, soft, and dry extracts as well as in softgels, capsules, and tablets in the presence of common excipients. The ability to address kavalactones in beverages is an advantage but not a requirement. No limit on analysis time is imposed.

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