the Stakeholder Panel on Dietary Supplements

Resveratrol cis/trans Chemistry

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Although trans-resveratrol is the biosynthetic product, UV exposure can isomerize it to the cis isomer. The 3-O-glucoside (piceid) is also produced by plants.

Resveratrol Bioactivities • In 1997, Pezzuto ( Science , 1987; 275: 218) discovered that resveratrol had cancer chemoprevention activity through multiple mechanisms of action • anti-inflammation (inhibits COX, iNOS, and NF-κB) • anti-oxidation (upregulates quinone reductase, glutathione, superoxide dismutase, and catalase) • induction of apoptosis • Subsequently, >20,000 papers have reported multiple other activities including • prevention of cardiovascular disease • anti-aging • neuroprotection