2019 AOAC Annual Meeting - Preliminary Program

Scientific SESSIONS SUNDAY, SEPTEMBER 8, 2019 1:00 pm – 2:30 pm TDRM Training Course: Selection and Use of Reference Materials This TDRM training course will offer a lot of useful information on how to select and use appropriate reference materials as they are key tools in analytical laboratories. How can the user make an educated guess which material is fit for purpose in their laboratory and what do the different concepts stated on the certificates mean in practice? Are some materials of a higher order or not? More specifically, the training course will provide information on material selection; handling and use, under- standing of property values and their uncertainties together with explanations on metrological traceability of measurement results. Buyers and users of reference materials receive a material data sheet or a certificate that accompanies the material. The documentation and the materials are inseparable and comple- mentary. The RM-users should pay close attention to what is stated in the documentation related to the materials regardless if the material is certified or non-certified. In fact, the differences on the documents are dictated by the material category i.e. whether the material is a certified reference material or a reference mate- rial without certified properties. What do these differences mean in practice? The training will be divided in four blocks to cover the process of selecting an appropriate reference material, proper handling of the material and measurement of the target parameters, estimat- ing the measurement uncertainty including a comparison with the certified value based on a simple calculation. Co-Chair : Håkan Emteborg, European Commission – Joint Research Centre Co-Chair : Charles Barber, U.S. National Institute of Standards and Technology Håkan Emteborg, European Commission, Joint Research Centre Charles Barber, U.S. National Institute of Standards and Technology 3:00 pm – 4:30 pm TDLM/TDRMWorkshop: What Auditors are Seeing as Top Findings for Laboratories Being Accredited to the ISO/IEC 17025:2017 Standard The 2017 version of the ISO/IEC 17025 standard has been in use for approximately one year and trends are beginning to present themselves as more and more assessments occur around the world. In this workshop, we will hear from accrediting bodies from the US and Canada, as well as an assessor and a labora- tory for their perspective.

Co-Chair : Brad Stawick, SGS North America, Inc. Co-Chair : John Szpylka, Mérieux NutriSciences Corporation Trace McInturff, A2LA - American Association for Laboratory Accreditation Colleen Cotter, CALA Brad Stawick, SGS North America, Inc. MONDAY, SEPTEMBER 9, 2019 1:00 pm – 1:30 pm Harvey W. Wiley Award Address: Nature Exposed to our Method of Questioning — Reliability of Measurements Made on Natural Products Joseph M. Betz, Ph.D., Office of Dietary Supplements, U.S. National Institutes of Health 1:30 pm – 3:00 pm Wiley Award Symposium: Advances in Analytical Methods for Botanical Dietary Supplements and for Clinical Nutritional Assessment The Harvey W. Wiley Award focuses on outstanding contri- butions to the development of analytical methods in areas of interest to AOAC INTERNATIONAL. The session in honor of the 2019 Wiley Awardee will focus on advances in analytical methods for the chemical characterization of botanical dietary supplements and for clinical nutritional assessment. Most dietary supplements contain natural product ingredients and are therefore complex mixtures of chemical constituents that require advanced chemical separations and detection, predominantly using liquid chromatography (LC) with mass spectrometry (MS) or tandem MS (MS/MS) detection, for chemical characteriza- tion. These advanced chemical analysis approaches are applied for qualitative and quantitative characterization of botanical products to support metabolomic studies, plant identification and authentication, efficacy studies, and safety and quality assess- ments. The importance of appropriate method selection and validation for the characterization of botanical products will be addressed. Regarding clinical nutritional assessment, the session will high- light an international effort to assist in the standardization of measurements for the determination of a clinically significant nutritional marker for vitamin D status, i.e., 25-hydroxyvitamin D. The approach to standardization included the develop- ment of higher-order reference methods based on LC-MS/ MS, the development of standard reference materials (SRMs) to provide quality assurance of 25(OH)D measurements, and interlaboratory assessments of the performance of routinely used immunoassay-based tests versus LC-MS/MS methods. Chair : Stephen A. Wise, National Institutes of Health

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