2019 AOAC Annual Meeting - Preliminary Program

NMR Advancement in Quality Control and Compendial Applications

Co-Chair : Melissa Phillips, U.S. National Institute of Standards and Technology Co-Chair : Laura Wood, U.S. National Institute of Standards and Technology Melanie Downs, Food Allergy Research and Resource Program Protein Food Allergens Katerina Mastovska, Eurofins Reference Material Needs in the Analysis of Chemical Contaminants and Residues Patrick Bird, PMB BioTek Consulting Are My Controls Sufficient, Overkill or Just Right for My Testing Needs? The Role of (certified) Reference Materials and QC Organisms in a Microbiology Laboratory Holly Johnson, American Herbal Products Association Authenticity, Fraud, Adulteration 1:00 pm – 2:30 pm Validation and Implementation of Emerging Methods for Food Allergen and Gluten Measurement Research on methods to quantitate food allergens started more than two decades ago and still continues by incorporating new technologies and applications that are sensitive, with low limits of quantitation and robust towards a variety of food matrices. Depending on the instrumentation and method complexity, multiple platforms based on different technologies are being developed for food allergen and gluten estimation. Over the past decade, advances in hardware, proteomics workflows and quantitation strategies along with the improved understanding of food matrix and processing effects have brought wide- spread application of mass spectrometry (MS) methods. What advantages do these emerging methods offer and how do they compare with traditional methods for the detection food aller- gens and gluten? Are these methods ready for more widespread implementation or is additional research needed before adop- tion for routine analysis? Co-Chair : Girdhari Sharma, U.S. Food and Drug Administration Co-Chair : Melanie Downs, Food Allergy Research and Resource Program Prasad Rallabhandi, U.S. Food and Drug Administration Emerging Food Allergen and Gluten Testing Methods: Bioassays

Nuclear magnetic resonance spectroscopy (NMR) is a powerful analytical tool. It is unique for analysis with rich structural infor- mation, nondestructive to the sample, and inherently quantitative, linear in signal response. Especially, NMR can quantitate a compound purity even without the reference material, the so called “absolute quantification”. These unique features made NMR wide usage in quality control labs of GMP environment for both qualitative and qualitative analysis. These analyses ranging from small molecules to polymers include chemical and botani- cal identifications and purity determinations for raw material and products. The trend of using advanced NMR technique is further promoted by compendial organizations of USP, EP, JP etc. USP has promoted the use of NMR ranging from general mono- graphs on identity test of polysaccharides and glycoconjugates, screening for adulterants, to individual monographs on krill oil qualitative and quantitative analysis, Hydroxypropyl Corn Starch, and Chitosan analysis. This session will be focused on sharing progress and advance- ments in NMR applications in quality control labs and in compendial approaches, stimulating discussions on further application of this powerful technique for both food and dietary supplement community. Co-Chair : Quanyin Gao, Herbalife International of America Inc. Co-Chair : Peter Chang, Herbalife International of America Inc. Co-Chair : Gabriel Gianscaspro, U.S. Pharmacopeia (USP) NMR Advancements - Contract Lab Applications Congmei Cao, Herbalife International of America Inc. NMR Advancements - Food and Dietary Supplement Product’s Applications Amy Freund, Bruker Corporation NMR Advancements - From Diverse Instrumentation to Variety of Applications Food safety is a broad topic, ranging from heavy metals, toxins, and residue contamination resulting from growth conditions to allergens, bacteria, or other contamination occurring during processing and/or packaging. Food safety can also extend to authenticity, fraud, and adulteration, or even to potential spoilage. Each of these areas has unique needs with respect to accuracy controls and tools for increased measurement confi- dence. The speakers in this symposium will address the needs of four major areas of food safety, as well as various approaches that may assist laboratories with improving measurement capa- bilities. Time will be allotted at the end of the symposium for a brief roundtable discussion with the speakers. Gabriel Giancaspro, U.S. Pharmacopeia (USP) NMR Advancements - Compendia Applications Kristie Adams, Steelyard Analytics TDRM Symposium: Reference Material Needs for Food Safety

Francisco Dias Lourenco, Nima Labs, Inc. Handheld Devices for the Detection of Food Allergens and Gluten Linda Monaci, ISPA-CNR EU Collaborative Initiative on MS Methods for Allergen Analysis Katherine Fiedler, U.S. Food and Drug Administration Developing MS Allergen Methods for Regulatory Agency Use

WWW.AOAC.ORG 301.924.7077 25