AOAC 2018 Preliminary Program

• Luis Rodriguez-Saona, The Ohio State University Handheld and Portable Devices for in-situ Screening of Chemical Contaminants: Point-and-Shoot Capabilities of Vibrational Spectroscopy Combined with Pattern Recognition Techniques • James Harnly, U.S. Department of Agriculture The 3 Fundamentals of Non-Targeted Analysis: Reference Samples, Chemical Fingerprinting, and One-Class Modeling • Kenny Xie, U.S. Pharmacopeia (USP) Non-Targeted Detection of Milk Powder Adulteration by 1H NMR Spectroscopy and Conformity Index Analysis • Ashraf Ismail, McGill University Infrared Spectroscopic Methods for Detection of Adulterants in Raw Milk • Marcal Plans Pujolras, Nestlé Purina Uses of NIR Spectroscopy for Economically Motivated Adulteration (EMA) in Pet Food Industry Symposium: Quantitative NMR in Quality Control and Compendial Analysis The methodology and practice of quantitative NMR (qNMR) has seen significant advancements within the last decade following solidification of conceptual understanding, develop- ments in signal processing and software, as well as increased availability of moderately-priced sub-100 MHz, a.k.a. benchtop, instrumentation. It is evident that aforementioned advantages coupled with further developments in automation assemble into a compelling analytical platform, rivaling the position of chromatographic techniques. Growing recognition and acceptance of the methodology by analytical community, and propensity of the pharmacopoeias to incorporate qNMR procedures is a testament to the technique’s maturity and on overt acknowledgement of its powerful appeal. Dietary supplements, especially those of biogenic origin, are often exceedingly complex. It is for a reason that NMR and qNMR are frequently called upon as “techniques of last resort” with their notable ability to address matrices that challenge chromatographic paradigm and resolve difficulties with conventional detection: krill oil phospholipids, a dozen compo- nents of Aloe vera , complex botanical extracts and analytically challenging biopolymers are all known to benefit from use of NMR. Since 2014, Japanese Pharmacopoeia has been steadily introducing qNMR into natural product monographs, and using qNMR for reference standard purity assignment. National pharmacopoeias and metrological institutions are actively employing this primary relative technique. The session will review the appropriateness of qNMR to common anal- yses, provide overview of the state-of-the art hardware and software, touch upon the uniqueness of method validation and the use of reference materials in quantitation, and investigate its status within compendial analysis, with examples from Japanese and U.S. Pharmacopoeias. CO-CHAIR: Anton Bzhelyansky, U.S. Pharmacopeia (USP) CO-CHAIR: Tetsuhisa Goto, Central Scientific Commerce, Inc. • Toru Miura, FUJIFILM Wako Pure Chemical Corporation Quantitation Paradigm in qNMR and Preparation of Quantitative Reference Standards • Kristie Adams, Steelyard Analytics, Inc. FutureQC: Applications You’d Love Running

• John Edwards, Process NMR Associates Industrial qNMR Using Low-Field Instrumentation: Perspectives and Progress • Yang Liu, U.S. Pharmacopeia (USP) Pharmacopeial qNMR: Laying the Foundation for the Future of Compendial Analysis Symposium: How Can Interlaboratory Studies Help your Laboratory and the Community At-Large? Accurate and precise measurements are vital to confident decision making in the regulation of natural products. Many measurement service tools are available to help laboratories critically evaluate performance, including Official Methods of Analysis, reference materials, and interlaboratory stud- ies. Interlaboratory studies often follow a proficiency testing model used for the purpose of laboratory certification/ accreditation. The Chemical Sciences Division (CSD) at NIST provides interlaboratory studies for additional purposes including: establishing scientific validity of a method; uncovering method specific results and biases; evaluating commutability of reference materials; and performing collab- orative studies to gather multi-laboratory testing data to support recommendation of methods from first to final action. The programs are designed to be of use to laboratories large and small that support production of materials along all points in the supply chain. This session will explore the less commonly discussed benefits of interlaboratory studies. CO-CHAIR: Laura Wood, U.S. National Institute of Standards and Technology CO-CHAIR: Charles Barber, U.S. National Institute of Standards and Technology • Melissa Phillips, U.S. National Institute of Standards and Technology An Incremental Approach to Collaborative Studies using Quality Assurance Programs • Rupa Das, BI Nutraceuticals The Value of QAPs in Supply Chain Management • Donald Gilliland, Abbott Laboratories Use of Interlaboratory Studies to Evaluate Laboratory and Methods Performance – An Industry Perspective • Joseph Betz, National Institutes of Health The Benefits of QAPs from an NIH Perspective • Catherine Rimmer, U.S. National Institute of Standards and Technology Bringing It All Together HAMQAP

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