AOAC 2018 Preliminary Program

methods for veterinary drug residues analysis in food using LC-Mass Spectrometry. The discussions and presentations include: 1. Extraction of both polar and non-polar veterinary drugs in a single extraction procedure or an analytical run. 2. Emerging detection technologies such as new generation triple quadrupole (QQQ), or (Q) Orbital Trap and (Q) Time-of-Flight. 3. Method validation guidelines and the method performance criteria, especially for screening based on High Mass- Resolution Mass Spectrometry. Overall, the session will be of interest to scientists and managers of analytical laboratories to increase their sample throughput or improve monitoring efficiency. CO-CHAIR: Eric Verdon, ANSES - Laboratory of Fougeres CO-CHAIR: Jian Wang, Canadian Food Inspection Agency (CFIA) • Steven Lehotay, U.S. Department of Agriculture Continued Progress in the Multi-class, Multi-residue Analysis of Veterinary Drugs in Animal Tissues • Anton Kaufmann, Official Food Control Authority of the Canton of Zurich Unified HRMS Based Workflows Integrating the Quantification and Confirmation of Veterinary Drugs • Thierry Delatour, Nestec Ltd. - Nestlé Research Center A streamlined LC-MS/MS Platform for the Screening and Confirmation of 152 Veterinary Drug Residues in a Broad Range of Food Raw Materials, Processed Ingredients and Finished Products 3:00 pm – 4:30 pm Symposium: Mycotoxins and Food Safety-Prevention and Control: Expectation and Reality The occurrence of mycotoxins in food and animal feed may pose a threat to human and animal health. To protect consum- ers and animals, many regulatory bodies have established measures to minimize dietary exposure to mycotoxins. To effectively enforce these established regulations, it is import- ant to establish surveillance and monitoring programs that can identify and analyze suspected commodities that are prone to mycotoxin contamination. The analysis of consumer prod- ucts via well-designed sampling plans and surveys can verify adherence with limits and update prevalence data for expo- sure studies and risk assessment. In reality, numerous factors play a role in the process of establishing new mycotoxin tolerances. How to ensure data quality remains a challenge for laboratories that perform mycotoxin analysis. More efforts are still required to improve quality assurance and analytical technologies. The need for certified reference materials in different matrices for mycotoxins of interest has not been met yet. Limited data currently exists on the degree of myco- toxins contamination in food products, making it difficult to determine the risk associated with the consumption of these food products by consumers, especially for infants and young

children. Therefore, this proposed symposium will focus on the following areas: 1. Prevention-based mycotoxin monitoring and surveillance strategies. 2. The importance role of reference materials in quality assurance. 3. Challenges in modified mycotoxin analysis. 4. The availability of survey data and risk assessment of co-occurrence of multiple mycotoxins in foods and feeds. CHAIR: Kai Zhang, U.S. Food and Drug Administration • Melissa Phillips, U.S. National Institute of Standards and Technology Value Assignment of a Multi-Mycotoxin Reference Material • Hyun Jung Lee, University of Idaho Reduction of Ochratoxin A during Food Processing • Songxue Wang, Academy of State Administration of Grain, China Perspectives on Risk Control of Mycotoxins in Post-Harvest Grain • Chris Maragos, U.S Department of Agriculture Detection of Modified Mycotoxins in Corn • Robert Lemieux, Canadian Food Inspection Agency (CFIA) Development and Validation of a Method to Determine Trichothecenes in Feed by LC-MS Symposium: Protein Qualitative and Quantitative Analysis Protein is an important nutrient widely used in both food and dietary supplement products. For soy protein ingredient, the market value is estimated to reach 12.84 Billion USD by 2022. There are multiple challenges for protein qualitative and quantitative analysis. The identification of soy protein from other protein sources (such as rice, pea, and milk) and quantitation of protein content to screen out adulterant are just a few examples of the challenges. The current Dumas and Kjeldahl methods are lack of specificity for nitrogen containing adulterant that calls for new method development. In particu- lar, Quality Control needs methods specific and fast in sample turnaround time for production support. Due to the large variety of the protein source, the discussion will be focused on soy protein. Currently, the qualitative and quantitative analysis methods for soy protein are diverse in terms of their principles, ranging from traditional combustion to modern Mass-spectrometric method. The Dumas method estimates the protein content by total nitrogen level after combustion but cannot distinguish nitrogen-containing materials like melamine. Lowry method, based on copper-binding, is a more specific colorimetric approach. Full amino acid profiling can give both ID and quantitation of protein content but the test takes longer time. Mass-spectrometric method is also applied to food protein quantification, adulteration detec- tion, and identification. ELISA historically used for detection of the allergens can potentially be used for identification of soy protein but can be too sensitive. This session will cover different technologies in protein assay methods of different organizations facing the challenge.

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