AOAC 2018 Preliminary Program

Symposium: Novel Analytical Methods for New Carbohydrates

Symposium: Can Quality Be Assured by Analytical Laboratories Testing Cannabis?

Carbohydrates are the most abundant group of natural prod- ucts and unambiguously one of the major macronutrients for human diet. Carbohydrates are not only an important energy source but also provide wide benefits by promoting health and well-being and reducing the risk of disease. On the other hand, certain carbohydrates, such as simple sugars and starch, are well documented in relation to negative health risks (e.g. diabetes, cardiovascular diseases etc.). For these reasons carbohydrates needed to be well determined and correctly labeled when present in food products. In parallel, the field of carbohydrates and carbohydrate analysis is in constant development with novel compounds (natural or synthetic) introduced in food products. However several of the currently available methods are not always able to correctly determine these novel compounds (sometimes even failing to determine several of them). The development of new methods is thus also an emerging topic. In the scientific session, several aspects regarding carbohy- drate analytical method development will be discussed. An overview of the past and future of carbohydrate analysis will deliver answers about the reasons of the existence of various methods for the same analyte and the advantages/disadvan- tages thereof. We will discuss the development of tools for the quantitation of human milk oligosaccharides, since these natural compounds have gained broad interest in academia and industries because of their important health benefits. We will also address the necessity and problems in accessing to carbohydrate standards by a lecture covering the newest development in preparative HPLC of carbohydrates. CO-CHAIR: Ioannis Vrasidas, Eurofins CO-CHAIR: Xun Yan, AMWAY • Ioannis Vrasidas, Eurofins Novel Analytical Methods for New Carbohydrates: An Introduction to the Session • Xun Yan, AMWAY The Past and Future of AOAC Carbohydrate Analytical Methods • Carlito Lebrilla, University of California Tools for the Rapid Throughput Quantitation of Human Milk Oligosaccharides and Other Glycoconjugates

Cannabis is in U.S. daily news and in 40 countries that also have de-criminalized or legalized. The cannabis plant is complex and not neatly categorized as dietary or nutritional supplement, food, or drug. Perhaps the single most univer- sally accepted fact is that cannabis is a synergistic substance, a dynamic system in and of itself. Third party and regulatory analytical testing laboratories are challenged by state regu- latory bodies and consumers to develop valid, effective and practical test methods to evaluate principle compounds in cannabis or cannabisladen matrices. Traditional analytical test methods endeavor to isolate, identify, and quantitate specific compounds in a specified matrix. Appropriately developed methods test samples from the larger population and infer derived sample results describe the population. Guidance methodologies by recognized sources are frequently employed by cannabis-testing laboratories, however there remains a lack of official, consensus methods subject to rigor- ous evaluation to ensure scientific integrity. AOACI and other organizations are diligently working toward establishing such methods, in partial fulfillment of the overall need to charac- terize specific components of interest. This session addresses the unspoken difficulty of applying traditional method devel- opment approaches to cannabis. We will discuss obvious and less obvious limitations of assuring quality in the attempt to isolate, identify, and quantitate specific in this dynamic system. We pose the possibility that cannabis test results may characterize only that sample in that moment in time, without inference to the larger population. We propose that these challenges may not be unique to cannabis and suggest pathways forward. CHAIR: Susan Audino, Audino & Associates, LLC • Susan Audino, Audino & Associates, LLC Analytical challenges to extract, isolate, identify, and quantitate specific components in a complex and dynamic matrix • M.L. Jane Weitzel, Consultant Cannabis: Tackling the challenge testing of complex things • Joe Konschnik, Restek Corporation Trusting Your Cannabis Testing Results Requires Trusting Your CRMs

• Arland Hotchkiss, U.S. Department of Agriculture Preparative HPLC of Dietary Fiber Oligosaccharides

26 AUGUST 26 – 29, 2018 SHERATON CENTRE TORONTO HOTEL