AOAC CASP Meeting - MYM 2020

DRAFT AOAC SMPR 2019.XXX; Version 6; March 11, 2020. 1 2 Method Name: 3

Determination of Heavy Metals in a Variety of Cannabis

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and Cannabis Derived Products

Approved by:

Final version date : Effective date:

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Intended Use :

Surveillance methods for routine monitoring

1. Applicability :

Determination of total cadmium (CAS No. 7440-43-9), total arsenic (CAS No. 7440- 38-2), total lead (CAS No. 7439-92-1), and total mercury (CAS No. 7439-97-6).

Additional elements in Table 1 may be included.

2. Analytical Technique :

Inductively Coupled Plasma based instrumentation or alternative methodology that

meets the performance requirements

3. Definitions :

Limit of Quantitation (LOQ)

The minimum concentration or mass of analyte in a given matrix that can be reported

as a quantitative result.

Repeatability

Variation arising when all efforts are made to keep conditions constant by using the same instrument and operator, and repeating during a short time period. Expressed as the repeatability standard deviation (SD r ); or % repeatability relative standard

deviation (%RSD r ).

Reproducibility

The standard deviation or relative standard deviation calculated from among- laboratory data. Expressed as the reproducibility relative standard deviation (SD R ); or

% reproducibility relative standard deviation (% RSD R ).

Recovery

The fraction or percentage of spiked analyte that is recovered when the test sample

is analyzed using the entire method.