AOAC GFA Stakeholder Program Meeting Book (August 27, 2023)

PAGE SEVEN – MATRIX STUDY DESIGN

Parameter

Number of Matrices and Concentrations

Repeatability

All matrices, 4 concentrations (blank, low, medium, and high) for each matrix All matrices, at least 3 concentrations (blank, low, medium) for each matrix All matrices, at least 3 concentrations (blank, low, medium) for each matrix All matrices, three non-blank concentrations (i.e., low, medium, and high)

Intermediate Precision

Sensitivity

Recovery

Table 3. Required Test Materials for Quantitative Study Designs

Parameter Column has a parameter called "Sensitivity" but there are no parameters in the document. I search in the document for this word, and it seems it is being used as a stand-in for LOD/LOQ concept. In Table 3 here, I'd ask to change this line to "LOD/LOQ" instead of "Sensitivity." Rationale: In other docs, "Sensitivity" is used as a stand-in for other concepts, like recovery, or the strength of response. I would avoid it in this document, since we have defined LOD and LOQ, and I can't see adding a definition for Sensitivity. Also, in places in the text where "sensitivity" is used, delete.

4.4 Matrix study table 3. Definition of Sensitivity?