AOAC Method Validation (August 29, 2018)

Limit of Detection (LOD)

Background Source: Guidelines for Single Laboratory Validation (SLV) of Chemical Methods for Metals in Food X Limit of Detection (LOD): The lowest concentration of analyte in a sample that can be detected, but not necessarily quantitated under the stated conditions of the test. X Limit of Detection : “The true net concentration or amount of the analyte in the material to be analyzed which will lead, with probability (1-ǃ WR WKH FRQFOXVLRQ WKDW WKH FRQFHQWUDWLRQ RU amount of the analyte in the analyzed material is larger than that in the blank material.

Limit of Detection (LOD)

Discussion