AOAC Method Validation (August 29, 2018)
Limit of Detection (LOD)
Background
X AOAC SMPRs routinely include criteria for limit of detection. X There have been a series of questions regarding LOD: X 1) definition; X 2) appropriate confidence level; and X 3) procedure for determination.
Limit of Detection (LOD)
Background X In recent years AOAC has used the following definition for LOD: βThe smallest amount or concentration of an analyte that can be estimated with acceptable reliability.β This definition is a simplification of the IUPAC definition. X ISO 12787:2011(en) Cosmetics β Analytical methods β Validation criteria for analytical results using chromatographic techniques 2.2.2 LoD - limit of detection - lowest amount of an analyte that can be reliably distinguished from zero with reasonable statistical certainty.
Made with FlippingBook Online newsletter