Microsoft Word - Candidates for 2018 ERP of the Year

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Official Methods SM status.

9/0/1 (Abstain: Covance)

of GA and CS in Dietary Supplements

Secondary: Curtis Phinney

Submitted by: Frantisek Kvasnicka, University of Chemistry and Technology, Prague

CHON-003

Title: Chondroitin by IR and Dimethylmethylene Blue (DMMB) Spectrophotometry

Motion 1: MOTION to not move CHON-003 to First Action Official Methods SM status. Motion 2: MOTION to ask the method author whether they can provide additional data regarding the interfering compounds that are listed on the SMPR008 and if they have additional data for system suitability / all validation data. MOTION 1: MOTION to move CHON-004 to First Action Official Methods SM status. Motion 2: MOTION to be considered for Final Action Official Methods SM status, the author(s) should: • Optimize and control the moisture in the chondroitin sulfate including appropriate vessels and glassware.

Motion 1: Solyom/Spzylka 9/0/1 (Abstain: Covance)

Primary: Aniko Solyom Secondary: Nour Eddine Es-Safi

Submitted by: Xun Yan, Amway

Motion 2: Solyom/Hildreth 9/0/1 (Abstain: Covance) Motion 1: Sullivan/Koerner, 8/0/2 (Abstain: Covance, Hildreth) Motion 2: Sullivan/Reins 8/0/2 (Abstain: Covance, Hildreth)

CHON-004

Title: Determination of Chondroitin Sulfate Content in Raw Materials and Dietary Supplements by High- Performance Liquid Chromatography with Ultraviolet Detection After Enzymatic Hydrolysis

Primary: Darryl Sullivan

Secondary: Phillip Koerner

Submitted by: David Ji, Analytical Laboratories in Anaheim, Inc.

• • • •

Investigate alternative LC columns.

Optimize the LC conditions.

Look at lessons learned from USP.

Include a potency evaluation of the enzyme use. Investigate use of the USP standard that is currently available. Certified reference material recommended.

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03/12/2018