Microsoft Word - Draft OMB Meeting Agenda-April 11 2019

OMB Meeting 4-11-2019 Pre-read Materials

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TN-1208

Figure 7. Representative Chromatogram of 15 ng/mL standard

3

9370 9000 8500 8000 7500 7000 6500 6000 5500 5000 4500 4000 3500 3000 2500 2000 1500 1000 500

1. Cyanocobalamin 2. Adenosylcobalamin 3. Methylcobalamin

2

1

0 Area, counts Intensity, cps 1.3e5 1.2e5 1.1e5 1.0e5 9.0e4 8.0e4 7.0e4 6.0e4 5.0e4

App ID 23921

0.5

1.0

1.5

2.0

2.5

3.0

3.5

4.0

4.5

5.0 min

Figure 8. Representative Methylcobalamin Calibration Curve

Curve range: 1.5 - 50 ng/mL r = 0.9992

4.0e4

3.0e4

2.0e4

1.0e4

0.0

2

4

6 8 10 12 14 16 18 20 22 24 26 28 30 32 34 36 38 40 42 44 46 48 50

04/05/2019