PFAS Meeting Book MYM 2023

Specific performance criteria

Table 2: Mass spectrometric performance and peak identification criteria

(U)HPLC-LRMS

Unit mass resolution

Typical systems (examples)

MS/MS triple quadrupole, ion trap, Q-trap, Q-TOF, Q-Orbitrap

Acquisition

Selected or multiple reaction monitoring (SRM, MRM)

Minimum number of ions

2 product ions

Ion ratio from sample extracts should be within ± 30 % (relative) of average of calibration standards from same sequence.

Ion ratio

Signal to noise (S/N) ratio

≥ 3

The ratio of the chromatographic RT of the analyte to that of the IS (i.e. relative RT of the analyte) shall correspond to that of the calibration standard with a maximum deviation of 1 %. Analyte peaks from both product ions in the extracted ion chromatograms must fully overlap.

Retention time (RT)

Other

AOAC Midyear Meeting - Overview of EURL PFAS Guidance Document

16.03.2023

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