SPIFAN Nutrients ERP Book_9-29-15

Fluor-02 SLV FOR ERP USE ONLY DO NOT DISTRIBUTE

peak noise between 6.5 and 7.0 min over five injections of a prepared sample. The estimated LOD and LOQ for fluoride were 1.30 and 4.31 µ g/L respectively.

Summary

The accuracy data for fluoride met the criteria specified in the SMPR (RSD ≤ 15%) with the exception of AN high fat sample with RSD of 15.3%. The limit of quantitation was estimated to be 4.31 µ g/L. The limit of detection was estimated to be 1.30 µ g/L. Acceptable linearity was demonstrated over a range of 20 to 1000 µg/L. This method is found to be suitable for the analysis of fluoride in IF and AN formulas except few samples didn’t comply with some of the SMPR specifications. This is due to the fact that fluoride is present in very low concentrations in these products. Sample preparation used in this method was optimized to achieve the analysis of both fluoride and chloride anions in a single method. Further optimization of the method can be done (less sample dilution) to reevaluate the fluoride in IF and AN products.