the Stakeholder Panel on Dietary Supplements

Background

Molecular Structure of (S, S) S - Adenosyl-L-Methionine

NH 2

N

N

CH 3

(S)

_

+

(S)

S

OOC H 2 N

N N

O

H

HO OH

Background

SAMe Finished Products (Dietary Supplements)

• One of the most popular dietary supplements; • Popular Product Format: Tablets in Blister Pack; • Dosage: 200mg-400mg/Tablet, 2-4 Tablets daily; • Principal Structure Function: Methyl Donor • Medical Uses: Depression, Parkinson’s, Osteoarthritis, Liver disease …