the Stakeholder Panel on Dietary Supplements

Challenge: SAMe’s Extreme Instability

• S-adenosyl-L-homocysteine (SAH) • Adenosine (ADE) • Deoxy-methylthioadenosine (DMTA) • Etc… Irreversible, Significant

Degradation

SAMe Bio-Active, (S,S)

(1)

(2)

SAMe Bio-Inactive, (R,S)

Reversible , Insignificant

SMPR Key Points

Method Name Determination of SAMe in Dietary Supplements and Dietary Ingredients Intended Use For quality assurance and compliance to current good manufacturing practices Applicability Determination of total (S,S and R,S isomers) SAM-e in dietary ingredients and dietary supplements

Analytical Technique Any analytical technique that meets the method performance requirements is acceptable