the Stakeholder Panel on Dietary Supplements

SMPR Key Points

Validation Guidance Method must be able to separate SAMe from:  1. Decomposition Products: • p‐toluenesulfonic acid (PTSA),  • S‐adenosylhomocysteine (SAH),  • Adenosine,  • 5'‐deoxy‐5'‐methylthioadenosine (DMTA).

SMPR Key Points

Validation Guidance Method must be able to separate SAMe from:  2. Synthetic Precursors / Stabilizing Agents: • Methionine,  • ATP (adenosine triphosphate),  • Toluene  • Sulfonic Acid